If you envisage having unprotected sex, treating local authority with contempt, taking no precautions against malaria, ignoring local advice about the localities of landmines or when bush (free) camping and insisting on driving at night, then Mozambique is a very risky place.
At all times beware of muggers in the bigger cities and petty thieving almost everywhere away from resorts. Note that it is essential to carry a medical evacuation insurance. I use TIC Travel Insurance to cover emergency air evacuation: www.tic.co.za
South Africa has excellent private hospitals and for example for emergency trauma you can do no better than the Milpark Hospital in Johannesburg tel + 27 11 – 480 5600, www.netcare.co.za)